Gene
clcn6
- ID
- ZDB-GENE-030131-2056
- Name
- chloride channel 6
- Symbol
- clcn6 Nomenclature History
- Previous Names
-
- wu:fb95f01
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable chloride transmembrane transporter activity. Predicted to act upstream of or within chloride transport and transmembrane transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human CLCN6 (chloride voltage-gated channel 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ceroid lipofuscinosis, neuronal, 15 | 619173 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000644 | CBS domain |
| Family | IPR001807 | Chloride channel, voltage gated |
| Family | IPR002248 | Chloride channel ClC-6 |
| Family | IPR051280 | Voltage-gated chloride channel/antiporter |
| Homologous_superfamily | IPR014743 | Chloride channel, core |
| Homologous_superfamily | IPR046342 | CBS domain superfamily |
Domain Details Per Protein
| Protein | Length | CBS domain | CBS domain superfamily | Chloride channel ClC-6 | Chloride channel, core | Chloride channel, voltage gated | Voltage-gated chloride channel/antiporter |
|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F798
|
863 |
Interactions and Pathways
No data available
Plasmids
No data available