Gene

usp8

ID
ZDB-GENE-030131-1949
Name
ubiquitin specific peptidase 8
Symbol
usp8 Nomenclature History
Previous Names
  • wu:fb15f07
  • wu:fb92h07
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have thiol-dependent ubiquitin-specific protease activity. Involved in regulation of cilium assembly. Predicted to localize to several cellular components, including extrinsic component of endosome membrane; midbody; and postsynaptic density. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With usp8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ACTH-secreting pituitary adenoma Alliance Pituitary adenoma 4, ACTH-secreting, somatic 219090
Associated With usp8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018200 Ubiquitin specific protease, conserved site
Domain IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Domain IPR001763 Rhodanese-like domain
Domain IPR015063 USP8 dimerisation domain
Domain IPR028889 Ubiquitin specific protease domain
Domain IPR048498 USP8, WW domain
Family IPR050185 Ubiquitin carboxyl-terminal hydrolase
Homologous_superfamily IPR036873 Rhodanese-like domain superfamily
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
Domain Details Per Protein
Protein Length Papain-like cysteine peptidase superfamily Peptidase C19, ubiquitin carboxyl-terminal hydrolase Rhodanese-like domain Rhodanese-like domain superfamily Ubiquitin carboxyl-terminal hydrolase Ubiquitin specific protease, conserved site Ubiquitin specific protease domain USP8 dimerisation domain USP8, WW domain
UniProtKB:A0A8M9P169 1067
UniProtKB:A0A8M3ARQ7 1066
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA usp8-201 (1) Ensembl 4,181 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations