Gene

clcn3

ID
ZDB-GENE-030131-1699
Name
chloride channel 3
Symbol
clcn3 Nomenclature History
Previous Names
  • fb78c02
  • wu:fb78c02
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have chloride ion binding activity; solute:proton antiporter activity; and voltage-gated chloride channel activity. Predicted to be involved in chloride transport and transmembrane transport. Predicted to localize to Golgi apparatus; cytoplasmic vesicle; and integral component of plasma membrane. Is expressed in several structures, including eye; female organism; heart; liver; and pleuroperitoneal region. Orthologous to human CLCN3 (chloride voltage-gated channel 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Thyme et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With clcn3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodevelopmental disorder with hypotonia and brain abnormalities 619512
Neurodevelopmental disorder with seizures and brain abnormalities 619517
Associated With clcn3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000644 CBS domain
Family IPR001807 Chloride channel, voltage gated
Family IPR002245 Chloride channel ClC-3
Homologous_superfamily IPR014743 Chloride channel, core
Homologous_superfamily IPR046342 CBS domain superfamily
Domain Details Per Protein
Protein Length CBS domain CBS domain superfamily Chloride channel ClC-3 Chloride channel, core Chloride channel, voltage gated
UniProtKB:A0A8M9Q891 799
UniProtKB:A0A8M9Q239 824
UniProtKB:A0A8M9PPD0 824
UniProtKB:A0A8M9QHF3 849
UniProtKB:A0A8M9Q887 874
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA clcn3-201 (1) Ensembl 2,550 nt
mRNA clcn3-202 (1) Ensembl 5,596 nt
mRNA clcn3-204 (1) Ensembl 518 nt
mRNA clcn3-205 (1) Ensembl 2,277 nt
ncRNA clcn3-004 (1) Ensembl 638 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations