Gene
prex1
- ID
- ZDB-GENE-030131-1428
- Name
- phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
- Symbol
- prex1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have Rac guanyl-nucleotide exchange factor activity. Involved in nodal signaling pathway. Predicted to localize to plasma membrane. Is expressed in endoderm. Orthologous to human PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Woo et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Woo et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
| Domain | IPR000219 | Dbl homology (DH) domain |
| Domain | IPR000591 | DEP domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Family | IPR051832 | Regulators of mTOR signaling and Rac activation |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | DEP domain | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | PDZ domain | PDZ superfamily | PH-like domain superfamily | Pleckstrin homology domain | Regulators of mTOR signaling and Rac activation | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1R6J2
|
1622 |
Interactions and Pathways
No data available
Plasmids
No data available