Gene
nqo1
- ID
- ZDB-GENE-030131-1226
- Name
- NAD(P)H dehydrogenase, quinone 1
- Symbol
- nqo1 Nomenclature History
- Previous Names
-
- wu:fb63c10
- zgc:77191
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable NAD(P)H dehydrogenase (quinone) activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be active in cytosol. Is expressed in several structures, including head; liver; neuromast; pleuroperitoneal region; and yolk. Human ortholog(s) of this gene implicated in several diseases, including agranulocytosis; breast cancer (multiple); hematologic cancer (multiple); lung disease (multiple); and small cell carcinoma. Orthologous to several human genes including NQO1 (NAD(P)H quinone dehydrogenase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6901454 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Benzene toxicity, susceptibility to} | |||
| {Breast cancer, poor survival after chemotherapy for} | |||
| {Leukemia, post-chemotherapy, susceptibility to} |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Flavodoxin-like fold | Flavoprotein-like superfamily | NAD(P)H dehydrogenase (quinone) |
|---|---|---|---|---|
|
UniProtKB:A0A2R8PW65
|
289 | |||
|
UniProtKB:Q6P0H2
|
275 |
Interactions and Pathways
No data available
Plasmids
No data available