Gene
tat
- ID
- ZDB-GENE-030131-1144
- Name
- tyrosine aminotransferase
- Symbol
- tat Nomenclature History
- Previous Names
-
- si:ch211-238a12.1
- wu:fb60g09
- zgc:154059
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have L-tyrosine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in L-phenylalanine catabolic process and biosynthetic process. Human ortholog(s) of this gene implicated in tyrosinemia and tyrosinemia type II. Is expressed in liver. Orthologous to human TAT (tyrosine aminotransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Cortés et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| tyrosinemia type II | Alliance | Tyrosinemia, type II | 276600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR004838 | Aminotransferases, class-I, pyridoxal-phosphate-binding site |
| Domain | IPR004839 | Aminotransferase, class I/classII, large domain |
| Family | IPR005957 | Tyrosine aminotransferase |
| Family | IPR005958 | Tyrosine/nicotianamine aminotransferase |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Length | Aminotransferase, class I/classII, large domain | Aminotransferases, class-I, pyridoxal-phosphate-binding site | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain | Tyrosine aminotransferase | Tyrosine/nicotianamine aminotransferase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0JMN6
|
444 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available