Gene
tat
- ID
- ZDB-GENE-030131-1144
- Name
- tyrosine aminotransferase
- Symbol
- tat Nomenclature History
- Previous Names
-
- si:ch211-238a12.1
- wu:fb60g09
- zgc:154059
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable L-tyrosine:2-oxoglutarate aminotransferase activity. Predicted to be involved in L-phenylalanine catabolic process and tyrosine catabolic process. Predicted to act upstream of or within aromatic amino acid metabolic process and biosynthetic process. Is expressed in liver. Human ortholog(s) of this gene implicated in tyrosinemia and tyrosinemia type II. Orthologous to human TAT (tyrosine aminotransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Cortés et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| tyrosinemia type II | Alliance | Tyrosinemia, type II | 276600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR004838 | Aminotransferases, class-I, pyridoxal-phosphate-binding site |
| Domain | IPR004839 | Aminotransferase, class I/classII, large domain |
| Family | IPR005957 | Tyrosine aminotransferase |
| Family | IPR005958 | Tyrosine/nicotianamine aminotransferase |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Length | Aminotransferase, class I/classII, large domain | Aminotransferases, class-I, pyridoxal-phosphate-binding site | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain | Tyrosine aminotransferase | Tyrosine/nicotianamine aminotransferase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0JMN6
|
444 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available