Gene
drd3
- ID
- ZDB-GENE-021119-1
- Name
- dopamine receptor D3
- Symbol
- drd3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in G protein-coupled receptor signaling pathway; negative regulation of cytosolic calcium ion concentration; and negative regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in myotome; nervous system; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential tremor 1 | Alliance | {Essential tremor, hereditary, 1} | 190300 |
| schizophrenia | Alliance | {Schizophrenia, susceptibility to} | 181500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Dopamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|
|
UniProtKB:Q8AWE1
|
454 | |||
|
UniProtKB:F1QG18
|
472 | |||
|
UniProtKB:A0A8M9PTW6
|
467 |
Interactions and Pathways
No data available
Plasmids