Gene

mapk14b

ID

ZDB-GENE-021007-1

Name

mitogen-activated protein kinase 14b

Symbol

mapk14b Nomenclature History

Previous Names

p38b (1)
zp38b (1)

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable MAP kinase activity. Predicted to be involved in several processes, including p38MAPK cascade; positive regulation of cell differentiation; and positive regulation of myoblast fusion. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Krens et al., 2006

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mapk14b Human Ortholog

No data available

Associated With mapk14b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR017441	Protein kinase, ATP binding site
Conserved_site	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
Domain	IPR000719	Protein kinase domain
Family	IPR008352	Mitogen-activated protein (MAP) kinase p38-like
Family	IPR050117	Mitogen-activated protein kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Mitogen-activated protein kinase	Mitogen-activated protein (MAP) kinase, conserved site	Mitogen-activated protein (MAP) kinase p38-like	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily
UniProtKB:F1RAA2 InterPro	361
UniProtKB:Q9DGE1 InterPro	348
UniProtKB:F1QQ40 InterPro	361

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mapk14b-201 (1) Ensembl	Ensembl	4,174 nt	Select Tool ZFIN BLAST
mRNA	mapk14b-202 (1) Ensembl	Ensembl	1,838 nt	Select Tool ZFIN BLAST
mRNA	mapk14b-203 (1) Ensembl	Ensembl	1,531 nt	Select Tool ZFIN BLAST
ncRNA	mapk14b-004 (1) Ensembl	Ensembl	773 nt	Select Tool ZFIN BLAST
ncRNA	mapk14b-005 (1) Ensembl	Ensembl	806 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations