Gene
prrx1a
- ID
- ZDB-GENE-020905-5
- Name
- paired related homeobox 1a
- Symbol
- prrx1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have sequence-specific DNA binding activity. Involved in several processes, including atrial cardiac muscle cell action potential; epithelial to mesenchymal transition; and heart looping. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Is expressed in several structures, including cranial vault; fin; gill; mesenchyme; and mesoderm. Orthologous to human PRRX1 (paired related homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb329 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| agnathia-otocephaly complex | Alliance | Agnathia-otocephaly complex | 202650 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Paired mesoderm homeobox protein 1/2 |
|---|---|---|---|---|---|---|
|
UniProtKB:Q7T373
|
245 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prrx1a-201
(1)
|
Ensembl | 1,908 nt |
Interactions and Pathways
No data available
Plasmids