Gene

ahr1a

ID

ZDB-GENE-020531-2

Name

aryl hydrocarbon receptor 1a

Symbol

ahr1a Nomenclature History

Previous Names

ahr1
AHR2 (1)
ahra
zfAHR1

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have DNA binding activity; DNA-binding transcription factor activity; and protein dimerization activity. Involved in cellular response to organic cyclic compound. Predicted to localize to cytoplasm; nucleus; and transcription factor complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Is expressed in brain; heart; liver; and pleuroperitoneal region. Orthologous to human AHR (aryl hydrocarbon receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Seifinejad et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ahr1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
retinitis pigmentosa 85	Alliance	?Retinitis pigmentosa 85	618345
		Foveal hypoplasia 3	620958

Associated With ahr1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000014	PAS domain
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR013767	PAS fold
Family	IPR001067	Nuclear translocator
Family	IPR039091	Aryl hydrocarbon receptor/Aryl hydrocarbon receptor repressor
Homologous_superfamily	IPR035965	PAS domain superfamily
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily
Repeat	IPR001610	PAC motif