Gene

tbx18

ID

ZDB-GENE-020529-2

Name

T-box transcription factor 18

Symbol

tbx18 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including morphogenesis of embryonic epithelium; regulation of transcription by RNA polymerase II; and somitogenesis. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in CAKUT2. Is expressed in several structures, including medial longitudinal fasciculus; pectoral fin; pericardial region; proepicardial cluster; and segmental plate. Orthologous to human TBX18 (T-box transcription factor 18).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

38 figures from 18 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu307 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tbx18 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
CAKUT2	Alliance	Congenital anomalies of kidney and urinary tract 2	143400

Associated With tbx18 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018186	Transcription factor, T-box, conserved site
Domain	IPR046360	T-box transcription factor, DNA-binding domain
Family	IPR001699	T-box transcription factor
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR036960	T-box superfamily