Gene

nek8

ID

ZDB-GENE-020509-1

Name

NIMA-related kinase 8

Symbol

nek8 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Involved in heart looping; pronephros formation; and renal tubule development. Localizes to cilium. Human ortholog(s) of this gene implicated in nephronophthisis 9 and renal-hepatic-pancreatic dysplasia. Orthologous to human NEK8 (NIMA related kinase 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Fukui et al., 2012

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nek8 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nephronophthisis 9	Alliance	?Nephronophthisis 9	613824
renal-hepatic-pancreatic dysplasia	Alliance	Renal-hepatic-pancreatic dysplasia 2	615415
		Polycystic kidney disease 8	620903

Associated With nek8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR044120	Nek8, catalytic domain
Family	IPR051997	Serine/threonine-protein kinase NEK
Homologous_superfamily	IPR009091	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Repeat	IPR000408	Regulator of chromosome condensation, RCC1