Gene
invs
- ID
- ZDB-GENE-020507-2
- Name
- inversin
- Symbol
- invs Nomenclature History
- Previous Names
-
- wu:fe47e11
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have calmodulin binding activity. Involved in several processes, including morphogenesis of an epithelium; opsin transport; and urogenital system development. Localizes to cilium. Used to study ciliopathy. Human ortholog(s) of this gene implicated in nephronophthisis 2. Orthologous to human INVS (inversin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Simons et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephronophthisis 2 | Alliance | Nephronophthisis 2, infantile | 602088 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| ciliopathy | WT + MO3-invs | control | Tobin et al., 2008 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Dendritic Spine Regulation and Scaffold | IQ motif, EF-hand binding site |
|---|---|---|---|---|---|
|
UniProtKB:Q8UVC1
|
1021 | ||||
|
UniProtKB:A0A8M2B4V4
|
1026 |
Interactions and Pathways
No data available
Plasmids
No data available