Gene

igf1ra

ID

ZDB-GENE-020503-1

Name

insulin-like growth factor 1a receptor

Symbol

igf1ra Nomenclature History

Previous Names

IGF-IRa (1)
sb:eu1090
wu:fi20b10

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process and insulin-like growth factor binding activity. Involved in several processes, including animal organ development; fin regeneration; and insulin-like growth factor receptor signaling pathway. Predicted to localize to axon and insulin receptor complex. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Is expressed in several structures, including brain; digestive system; eye; gill; and reproductive system. Orthologous to human IGF1R (insulin like growth factor 1 receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

21 figures from 18 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu1090 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Schlueter et al., 2006
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With igf1ra Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Insulin-like growth factor I, resistance to	270450

Associated With igf1ra Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Conserved_site	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site
Domain	IPR000494	Receptor L-domain
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR003961	Fibronectin type III
Domain	IPR006211	Furin-like cysteine-rich domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Family	IPR016246	Tyrosine-protein kinase, insulin-like receptor
Family	IPR050122	Receptor Tyrosine Kinase
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036941	Receptor L-domain superfamily
Repeat	IPR006212	Furin-like repeat

Domain Details Per Protein

Protein	Length	Fibronectin type III	Fibronectin type III superfamily	Furin-like cysteine-rich domain	Furin-like repeat	Growth factor receptor cysteine-rich domain superfamily	Immunoglobulin-like fold	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Receptor L-domain	Receptor L-domain superfamily	Receptor Tyrosine Kinase	Serine-threonine/tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, insulin-like receptor	Tyrosine-protein kinase, receptor class II, conserved site
UniProtKB:A0A8N7UZS2 InterPro	1405
UniProtKB:A0A8M6YTF7 InterPro	1404

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	igf1ra-201 (1) Ensembl	Ensembl	6,276 nt	Select Tool
mRNA	igf1ra-203 (1) Ensembl	Ensembl	4,302 nt	Select Tool ZFIN BLAST
ncRNA	igf1ra-002 (1) Ensembl	Ensembl	578 nt	Select Tool

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations