Gene
kif11
- ID
- ZDB-GENE-020426-1
- Name
- kinesin family member 11
- Symbol
- kif11 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Involved in angiogenesis; neurogenesis; and regulation of cell cycle. Predicted to localize to kinesin complex; nucleus; and spindle microtubule. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Is expressed in blood island; central nervous system; proliferative region; radial glial cell; and trunk. Orthologous to human KIF11 (kinesin family member 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| microcephaly with or without chorioretinopathy, lymphedema, or mental retardation | Alliance | Microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development | 152950 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR001752 | Kinesin motor domain |
| Domain | IPR025901 | Kinesin-associated microtubule-binding domain |
| Domain | IPR047241 | Kinesin-like protein KIF11-like, kinesin motor domain |
| Family | IPR047149 | Kinesin-like protein KIF11-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Kinesin-associated microtubule-binding domain | Kinesin-like protein KIF11-like | Kinesin-like protein KIF11-like, kinesin motor domain | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P8S1
|
1012 | |||||||
|
UniProtKB:A0A8M9P014
|
1061 | |||||||
|
UniProtKB:F1QK82
|
1062 |
Interactions and Pathways
No data available
Plasmids
No data available