Gene
vps18
- ID
- ZDB-GENE-020419-33
- Name
- VPS18 core subunit of CORVET and HOPS complexes
- Symbol
- vps18 Nomenclature History
- Previous Names
-
- chunp6929
- hm:zehl0587
- wu:fj35h10 (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within several processes, including apical protein localization; endosome to pigment granule transport; and notochord cell vacuolation. Predicted to be located in late endosome membrane and lysosomal membrane. Predicted to be part of HOPS complex. Predicted to be active in endosome. Used to study cholestasis. Orthologous to human VPS18 (VPS18 core subunit of CORVET and HOPS complexes).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103535 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cholestasis | vps18hi2499aTg | standard conditions | Sadler et al., 2005 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Clathrin, heavy chain/VPS, 7-fold repeat | Pep3/Vps18/deep orange, beta-propeller domain |
|---|---|---|---|
|
UniProtKB:P59015
|
974 | ||
|
UniProtKB:B7ZVV5
|
974 |
Interactions and Pathways
No data available
Plasmids
No data available