Gene

sf3b4

ID

ZDB-GENE-020419-22

Name

splicing factor 3b, subunit 4

Symbol

sf3b4 Nomenclature History

Previous Names

chunp6902
fb36a04
wu:fb36a04 (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to enable RNA binding activity. Acts upstream of or within regulation of retina development in camera-type eye and visual behavior. Predicted to be located in nucleus. Predicted to be part of U2 snRNP and precatalytic spliceosome. Is expressed in head. Human ortholog(s) of this gene implicated in Nager acrofacial dysostosis; cervical cancer; and hepatocellular carcinoma. Orthologous to human SF3B4 (splicing factor 3b subunit 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:85842 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sf3b4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Nager acrofacial dysostosis	Alliance	Acrofacial dysostosis 1, Nager type	154400

Associated With sf3b4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR034158	SF3B4, RNA recognition motif 1
Domain	IPR034159	SF3B4, RNA recognition motif 2
Family	IPR052084	Spliceosome-associated SF3B4 subunit
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily