Gene

sec61a1a

ID

ZDB-GENE-020418-2

Name

SEC61 translocon subunit alpha 1a

Symbol

sec61a1a Nomenclature History

Previous Names

fb62c11
sec61a1
sec61a
sec61al1 (1)
chunp6898
wu:fb62c11 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Involved in habenula development and pronephric nephron development. Predicted to localize to Sec61 translocon complex. Human ortholog(s) of this gene implicated in familial juvenile hyperuricemic nephropathy. Is expressed in several structures, including axis; digestive system; hatching gland; midbrain hindbrain boundary; and polster. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6907835 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sec61a1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Immunodeficiency, common variable, 15	620670
		Tubulointerstitial kidney disease, autosomal dominant, 5	617056
		?Neutropenia, severe congenital, 11, autosomal dominant	620674

Associated With sec61a1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR030659	SecY conserved site
Domain	IPR019561	Translocon Sec61/SecY, plug domain
Family	IPR002208	SecY/SEC61-alpha family
Homologous_superfamily	IPR023201	SecY domain superfamily