Gene

fabp3

ID

ZDB-GENE-020318-2

Name

fatty acid binding protein 3, muscle and heart

Symbol

fabp3 Nomenclature History

Previous Names

fabp11
H-FABP (1)
O-FABP
cb889 (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have lipid binding activity. Involved in chordate embryonic development and heart looping. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Is expressed in several structures, including immature eye; muscle; nervous system; pharyngeal arch; and pleuroperitoneal region. Orthologous to human FABP3 (fatty acid binding protein 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb889 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fabp3 Human Ortholog

No data available

Associated With fabp3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital heart disease	WT + MO1-fabp3	standard conditions	Wang et al., 2013
congenital heart disease	WT + MO2-fabp3	standard conditions	Wang et al., 2013

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000463	Cytosolic fatty-acid binding
Domain	IPR000566	Lipocalin/cytosolic fatty-acid binding domain
Family	IPR031259	Intracellular lipid binding protein
Homologous_superfamily	IPR012674	Calycin