Gene
gria1b
- ID
- ZDB-GENE-020125-2
- Name
- glutamate receptor, ionotropic, AMPA 1b
- Symbol
- gria1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have AMPA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to localize to AMPA glutamate receptor complex; dendritic spine; and postsynaptic density membrane. Is expressed in nervous system and otic vesicle. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu293 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 76 | Alliance | ?Intellectual developmental disorder, autosomal recessive 76 | 619931 |
| Intellectual developmental disorder, autosomal dominant 67 | 619927 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001320 | Ionotropic glutamate receptor, C-terminal |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
| Family | IPR015683 | Ionotropic glutamate receptor |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
Domain Details Per Protein
| Protein | Length | Ionotropic glutamate receptor | Ionotropic glutamate receptor, C-terminal | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|
|
UniProtKB:Q71E64
|
917 | |||||
|
UniProtKB:F1RE87
|
||||||
|
UniProtKB:E7F1V8
|
917 | |||||
|
UniProtKB:A0A8M3AU00
|
831 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
gria1b-203
(1)
|
Ensembl | 992 nt | ||
| mRNA |
gria1b-201
(1)
|
Ensembl | 3,816 nt | ||
| mRNA |
gria1b-202
(1)
|
Ensembl | 3,515 nt |
Interactions and Pathways
No data available
Plasmids
No data available