Gene

cebpa

ID

ZDB-GENE-020111-2

Name

CCAAT enhancer binding protein alpha

Symbol

cebpa Nomenclature History

Previous Names

c/ebpa (1)
cb1062 (1)
chunp6777
fj20f03
unm_sm1120
wu:fj20f03 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Exhibits DNA binding activity and DNA-binding transcription factor activity. Involved in hematopoietic stem cell migration; hemopoiesis; and liver development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Is expressed in several structures, including digestive system; hematopoietic cell; hematopoietic system; mesoderm; and yolk syncytial layer. Orthologous to human CEBPA (CCAAT enhancer binding protein alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

64 figures from 49 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb1062 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cebpa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	Leukemia, acute myeloid, somatic	601626
acute myeloid leukemia	Alliance	?Leukemia, acute myeloid	601626

Associated With cebpa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004827	Basic-leucine zipper domain
Family	IPR016468	CCAAT/enhancer-binding protein, chordates
Family	IPR031106	CCAAT/enhancer-binding protein C/EBP
Homologous_superfamily	IPR046347	Basic-leucine zipper domain superfamily