Gene

adh5

ID

ZDB-GENE-011003-1

Name

alcohol dehydrogenase 5

Symbol

adh5 Nomenclature History

Previous Names

ADH3 (1)
fb60b11
gsnor (1)
wu:fb60b11

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity; alcohol dehydrogenase (NAD+) activity; and zinc ion binding activity. Predicted to be involved in formaldehyde catabolic process. Predicted to be active in cytosol. Is expressed in several structures, including blastodisc; central nervous system; digestive system; pleuroperitoneal region; and trunk. Human ortholog(s) of this gene implicated in AMED syndrome and asthma. Orthologous to human ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77553 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Cox et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adh5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
AMED syndrome	Alliance	AMED syndrome, digenic	619151

Associated With adh5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR002328	Alcohol dehydrogenase, zinc-type, conserved site
Domain	IPR013149	Alcohol dehydrogenase-like, C-terminal
Domain	IPR013154	Alcohol dehydrogenase-like, N-terminal
Domain	IPR020843	Polyketide synthase, enoylreductase domain
Family	IPR014183	Alcohol dehydrogenase class III
Homologous_superfamily	IPR011032	GroES-like superfamily
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily