Gene

angptl3

ID

ZDB-GENE-010817-3

Name

angiopoietin-like 3

Symbol

angptl3 Nomenclature History

Previous Names

fb60e11
fb66h02
wu:fb60e11 (1)
wu:fb66h02

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Involved in hepatocyte proliferation and lipid metabolic process. Human ortholog(s) of this gene implicated in familial hypobetalipoproteinemia 2. Is expressed in liver; liver primordium; and yolk syncytial layer. Orthologous to human ANGPTL3 (angiopoietin like 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu543 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Lee et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With angptl3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial hypobetalipoproteinemia 2	Alliance	Hypobetalipoproteinemia, familial, 2	605019

Associated With angptl3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Family	IPR050373	Fibrinogen C-terminal domain-containing protein
Homologous_superfamily	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Homologous_superfamily	IPR036056	Fibrinogen-like, C-terminal