Gene
copb2
- ID
- ZDB-GENE-010724-7
- Name
- COPI coat complex subunit beta 2
- Symbol
- copb2 Nomenclature History
- Previous Names
-
- dop
- dopey
- sb:cb121
- wu:fb30f06
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have structural molecule activity. Involved in notochord development and somite development. Predicted to localize to COPI vesicle coat. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 19. Is expressed in several structures, including axial mesoderm; cardiovascular system; digestive system; fin; and nervous system. Orthologous to human COPB2 (COPI coat complex subunit beta 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb121 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary autosomal recessive microcephaly 19 | Alliance | ?Microcephaly 19, primary, autosomal recessive | 617800 |
| Osteoporosis, childhood- or juvenile-onset, with developmental delay | 619884 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006692 | Coatomer, WD associated region |
| Family | IPR016453 | Coatomer beta' subunit (COPB2) |
| Family | IPR050844 | Coatomer complex subunit |
| Homologous_superfamily | IPR011044 | Quinoprotein amine dehydrogenase, beta chain-like |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
| Repeat | IPR020472 | G-protein beta WD-40 repeat |
Domain Details Per Protein
| Protein | Length | Coatomer beta' subunit (COPB2) | Coatomer complex subunit | Coatomer, WD associated region | G-protein beta WD-40 repeat | Quinoprotein amine dehydrogenase, beta chain-like | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6JWU7
|
934 |
Interactions and Pathways
No data available
Plasmids
No data available