Gene
apoea
- ID
- ZDB-GENE-010724-18
- Name
- apolipoprotein Ea
- Symbol
- apoea Nomenclature History
- Previous Names
-
- ApoE-1 (1)
- im:7036787
- wu:fb69a05
- zgc:110064
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable cholesterol transfer activity; phosphatidylcholine-sterol O-acyltransferase activator activity; and phospholipid binding activity. Predicted to be involved in several processes, including acylglycerol homeostasis; cholesterol efflux; and phospholipid efflux. Predicted to act upstream of or within lipid transport and lipoprotein metabolic process. Predicted to be located in extracellular region. Predicted to be part of several cellular components, including chylomicron; low-density lipoprotein particle; and very-low-density lipoprotein particle. Predicted to be active in extracellular vesicle. Is expressed in brain; female organism; liver; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110064 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Hwang et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 1 | Alliance | {?Macular degeneration, age-related} | 603075 |
| Alzheimer's disease 2 | Alliance | Alzheimer disease 2 | 104310 |
| Alzheimer's disease 3 | Alliance | {?Alzheimer disease, protection against, due to APOE3-Christchurch} | 607822 |
| hyperlipoproteinemia type III | Alliance | Hyperlipoproteinemia, type III | 617347 |
| hyperlipoproteinemia type III | Alliance | {Coronary artery disease, severe, susceptibility to} | 617347 |
| sea-blue histiocytosis | Alliance | Sea-blue histiocyte disease | 269600 |
| Lipoprotein glomerulopathy | 611771 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Apolipoprotein A1/A4/E | Apolipoprotein A/E |
|---|---|---|---|
|
UniProtKB:Q503V2
|
269 |
Interactions and Pathways
No data available
Plasmids