Gene

epha3

ID
ZDB-GENE-010724-10
Name
eph receptor A3
Symbol
epha3 Nomenclature History
Previous Names
  • epha3l
  • si:ch211-176k6.1
  • si:dkey-114e9.1
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable transmembrane-ephrin receptor activity. Acts upstream of or within mesoderm migration involved in gastrulation and somitogenesis. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in optic cup. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human EPHA3 (EPH receptor A3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With epha3 Human Ortholog
No data available
Associated With epha3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001090 Ephrin receptor ligand binding domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR001660 Sterile alpha motif domain
Domain IPR003961 Fibronectin type III
Domain IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR027936 Ephrin receptor, transmembrane domain
Domain IPR034266 Ephrin type-A receptor 3, ligand binding domain
Family IPR016257 Ephrin receptor type-A /type-B
Family IPR050449 Ephrin receptor tyrosine kinases
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Ephrin receptor ligand binding domain Ephrin receptor, transmembrane domain Ephrin receptor type-A /type-B Ephrin receptor tyrosine kinases Ephrin type-A receptor 3, ligand binding domain Fibronectin type III Fibronectin type III superfamily Galactose-binding-like domain superfamily Immunoglobulin-like fold Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Sterile alpha motif domain Sterile alpha motif/pointed domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase ephrin type A/B receptor-like Tyrosine-protein kinase, receptor class V, conserved site
UniProtKB:A0A8M3B5I9
InterPro
980
UniProtKB:A0A8M3B2K7
InterPro
971
UniProtKB:A0A8M3AVX1
InterPro
981
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA epha3-201 (1)
Ensembl
Ensembl 8,443 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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