Gene

efnb1

ID

ZDB-GENE-010618-2

Name

ephrin-B1

Symbol

efnb1 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have ephrin receptor binding activity. Involved in embryonic liver development and optic vesicle morphogenesis. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in craniofrontonasal syndrome and dysostosis. Is expressed in several structures, including alar plate midbrain region; central nervous system; hepatoblast; intestinal rod; and liver and biliary system. Orthologous to human EFNB1 (ephrin B1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu368 (18 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With efnb1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
craniofrontonasal syndrome	Alliance	Craniofrontonasal dysplasia	304110

Associated With efnb1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019765	Ephrin, conserved site
Domain	IPR001799	Ephrin receptor-binding domain
Family	IPR031328	Ephrin
Homologous_superfamily	IPR008972	Cupredoxin