Gene
ehmt2
- ID
- ZDB-GENE-010501-6
- Name
- euchromatic histone-lysine N-methyltransferase 2
- Symbol
- ehmt2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have histone-lysine N-methyltransferase activity; p53 binding activity; and zinc ion binding activity. Involved in camera-type eye photoreceptor cell differentiation; exocrine pancreas development; and regulation of histone H3-K9 methylation. Predicted to localize to chromosome and nucleus. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Is expressed in brain; eye; and intestine. Orthologous to human EHMT2 (euchromatic histone lysine methyltransferase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001214 | SET domain |
| Domain | IPR007728 | Pre-SET domain |
| Domain | IPR038034 | Histone-lysine N-methyltransferase EHMT2, SET domain |
| Domain | IPR047762 | EHMT1/2, cysteine-rich region |
| Family | IPR043550 | Histone-lysine N-methyltransferase EHMT1/EHMT2 |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | EHMT1/2, cysteine-rich region | Histone-lysine N-methyltransferase EHMT1/EHMT2 | Histone-lysine N-methyltransferase EHMT2, SET domain | Pre-SET domain | SET domain | SET domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A8TT22
|
1173 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available