Gene

skic2

ID
ZDB-GENE-010430-5
Name
SKI2 subunit of superkiller complex
Symbol
skic2 Nomenclature History
Previous Names
  • skiv2l
  • fb70b07
  • wu:fb70b07
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have RNA helicase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay. Predicted to localize to Ski complex. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 2. Orthologous to human SKIV2L (Ski2 like RNA helicase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With skic2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
trichohepatoenteric syndrome 2 Alliance Trichohepatoenteric syndrome 2 614602
Associated With skic2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001650 Helicase, C-terminal domain-like
Domain IPR011545 DEAD/DEAH box helicase domain
Domain IPR012961 ATP-dependent RNA helicase Ski2/MTR4, C-terminal
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR025696 Exosome RNA helicase MTR4-like, beta-barrel domain
Domain IPR040801 Ski2, N-terminal domain
Domain IPR048392 Exosome RNA helicase MTR4-like, stalk
Family IPR016438 ATP-dependent RNA helicase SKI2-like
Family IPR050699 RNA/DNA Helicase
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length ATP-dependent RNA helicase SKI2-like ATP-dependent RNA helicase Ski2/MTR4, C-terminal DEAD/DEAH box helicase domain Exosome RNA helicase MTR4-like, beta-barrel domain Exosome RNA helicase MTR4-like, stalk Helicase, C-terminal domain-like Helicase superfamily 1/2, ATP-binding domain P-loop containing nucleoside triphosphate hydrolase RNA/DNA Helicase Ski2, N-terminal domain
UniProtKB:Q1LWQ1 1230
UniProtKB:F1R881 1249
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA skiv2l-201 (1) Ensembl 4,191 nt
mRNA skiv2l-203 (1) Ensembl 8,216 nt
ncRNA ottdart00000045245 (1) Ensembl 789 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations