Gene
dhfr
- ID
- ZDB-GENE-010406-5
- Name
- dihydrofolate reductase
- Symbol
- dhfr Nomenclature History
- Previous Names
-
- cb595 (1)
- zgc:86637
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Exhibits dihydrofolate reductase activity. Involved in folic acid metabolic process; heart contraction; and heart development. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Is expressed in several structures, including anterior neural tube; hematopoietic system; immature eye; nervous system; and neural plate. Orthologous to human DHFR (dihydrofolate reductase) and DHFR2 (dihydrofolate reductase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb595 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| megaloblastic anemia | Alliance | Megaloblastic anemia due to dihydrofolate reductase deficiency | 613839 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Dihydrofolate reductase | Dihydrofolate reductase domain | Dihydrofolate reductase-like domain superfamily |
|---|---|---|---|---|
|
UniProtKB:Q6IQS4
|
190 |
Interactions and Pathways
No data available
Plasmids
No data available