Gene
dvl3a
- ID
- ZDB-GENE-010319-1
- Name
- dishevelled segment polarity protein 3a
- Symbol
- dvl3a Nomenclature History
- Previous Names
-
- dvl3
- wu:fb75f04
- wu:fi22h02
- wu:fp61b09
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable frizzled binding activity. Involved in positive regulation of Wnt signaling pathway, planar cell polarity pathway. Acts upstream of or within canonical Wnt signaling pathway; convergent extension involved in axis elongation; and post-anal tail morphogenesis. Located in cell cortex and spindle. Is expressed in liver and male organism. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3 and lung cancer. Orthologous to human DVL3 (dishevelled segment polarity protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55261 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Xing et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant Robinow syndrome 3 | Alliance | Robinow syndrome, autosomal dominant 3 | 616894 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000591 | DEP domain |
| Domain | IPR001158 | DIX domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR003351 | Dishevelled protein domain |
| Domain | IPR024580 | Dishevelled C-terminal |
| Family | IPR008339 | Dishevelled family |
| Family | IPR015506 | Dishevelled-related protein |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
| Homologous_superfamily | IPR038207 | DIX domain superfamily |
Domain Details Per Protein
| Protein | Length | DEP domain | Dishevelled C-terminal | Dishevelled family | Dishevelled protein domain | Dishevelled-related protein | DIX domain | DIX domain superfamily | PDZ domain | PDZ superfamily | Ubiquitin-like domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B8JMI2
|
676 |
Interactions and Pathways
Plasmids