Gene
dvl3a
- ID
- ZDB-GENE-010319-1
- Name
- dishevelled segment polarity protein 3a
- Symbol
- dvl3a Nomenclature History
- Previous Names
-
- dvl3
- wu:fb75f04
- wu:fi22h02
- wu:fp61b09
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have frizzled binding activity. Involved in canonical Wnt signaling pathway; convergent extension involved in axis elongation; and post-anal tail morphogenesis. Localizes to cell cortex and spindle. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3. Is expressed in liver. Orthologous to human DVL3 (dishevelled segment polarity protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55261 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Xing et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant Robinow syndrome 3 | Alliance | Robinow syndrome, autosomal dominant 3 | 616894 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000591 | DEP domain |
| Domain | IPR001158 | DIX domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR003351 | Dishevelled protein domain |
| Domain | IPR024580 | Dishevelled C-terminal |
| Family | IPR008339 | Dishevelled family |
| Family | IPR015506 | Dishevelled-related protein |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
| Homologous_superfamily | IPR038207 | DIX domain superfamily |
Domain Details Per Protein
| Protein | Length | DEP domain | Dishevelled C-terminal | Dishevelled family | Dishevelled protein domain | Dishevelled-related protein | DIX domain | DIX domain superfamily | PDZ domain | PDZ superfamily | Ubiquitin-like domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B8JMI2
|
676 |
Interactions and Pathways
Plasmids