Gene

mapk14a

ID

ZDB-GENE-010202-2

Name

mitogen-activated protein kinase 14a

Symbol

mapk14a Nomenclature History

Previous Names

p38 (1)
p38a (1)
zp38a (1)
etID18993.8 (1)
fk28c03
hm:zeh1243
wu:fk28c03 (1)
zeh1243

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Exhibits MAP kinase activity. Involved in several processes, including embryonic cleavage; p38MAPK cascade; and regulation of collateral sprouting in absence of injury. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; otic vesicle; and pronephric duct. Orthologous to human MAPK14 (mitogen-activated protein kinase 14).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55209 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mapk14a Human Ortholog

No data available

Associated With mapk14a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR017441	Protein kinase, ATP binding site
Conserved_site	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
Domain	IPR000719	Protein kinase domain
Family	IPR008352	Mitogen-activated protein (MAP) kinase p38-like
Family	IPR038784	Mitogen-activated protein kinase 14
Family	IPR050117	Mitogen-activated protein kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Mitogen-activated protein kinase	Mitogen-activated protein kinase 14	Mitogen-activated protein (MAP) kinase, conserved site	Mitogen-activated protein (MAP) kinase p38-like	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily
UniProtKB:B2GPM7 InterPro	361
UniProtKB:A0A2R8QE41 InterPro	361
UniProtKB:Q9DGE2 InterPro	361

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mapk14a-201 (1) Ensembl	Ensembl	2,289 nt	Select Tool ZFIN BLAST
mRNA	mapk14a-203 (1) Ensembl	Ensembl	1,913 nt	Select Tool ZFIN BLAST
ncRNA	mapk14a-002 (1) Ensembl	Ensembl	736 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations