Gene

psmb12

ID

ZDB-GENE-001208-1

Name

proteasome 20S subunit beta 12

Symbol

psmb12 Nomenclature History

Previous Names

psmb11 (2)
beta1t (1)
zgc:92422

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have endopeptidase activity. Predicted to be involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to localize to cytoplasm; nucleus; and proteasome core complex. Human ortholog(s) of this gene implicated in ankylosing spondylitis; autoimmune hypersensitivity disease (multiple); lymphoma; psoriasis; and renal cell carcinoma. Orthologous to human PSMB9 (proteasome 20S subunit beta 9).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92422 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With psmb12 Human Ortholog

No data available

Associated With psmb12 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR016050	Proteasome beta-type subunit, conserved site
Family	IPR000243	Peptidase T1A, proteasome beta-subunit
Family	IPR001353	Proteasome, subunit alpha/beta
Family	IPR023333	Proteasome B-type subunit
Homologous_superfamily	IPR029055	Nucleophile aminohydrolases, N-terminal