Gene

epha4a

ID

ZDB-GENE-001207-7

Name

eph receptor A4a

Symbol

epha4a Nomenclature History

Previous Names

EphA4
cb246
ek2
etID309926.2 (1)
rtk1
sb:cb246
zek2
zgc:109882

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within several processes, including brain development; optic vesicle morphogenesis; and regulation of nervous system development. Predicted to be located in early endosome and membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; germ ring; mesoderm; neural keel; and neural tube. Orthologous to human EPHA4 (EPH receptor A4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

72 figures from 49 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb246 (13 images)
eu671 (23 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With epha4a Human Ortholog

No data available

Associated With epha4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Conserved_site	IPR001426	Tyrosine-protein kinase, receptor class V, conserved site
Domain	IPR000719	Protein kinase domain
Domain	IPR001090	Ephrin receptor ligand binding domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR001660	Sterile alpha motif domain
Domain	IPR003961	Fibronectin type III
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR027936	Ephrin receptor, transmembrane domain
Domain	IPR030602	Ephrin type-A receptor 4, SAM domain
Domain	IPR034270	Ephrin type-A receptor 4, ligand binding domain
Family	IPR016257	Ephrin receptor type-A /type-B
Family	IPR050449	Ephrin receptor tyrosine kinases
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily

Domain Details Per Protein

Protein	Length	Ephrin receptor ligand binding domain	Ephrin receptor, transmembrane domain	Ephrin receptor type-A /type-B	Ephrin receptor tyrosine kinases	Ephrin type-A receptor 4, ligand binding domain	Ephrin type-A receptor 4, SAM domain	Fibronectin type III	Fibronectin type III superfamily	Galactose-binding-like domain superfamily	Growth factor receptor cysteine-rich domain superfamily	Immunoglobulin-like fold	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	Sterile alpha motif domain	Sterile alpha motif/pointed domain superfamily	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, receptor class V, conserved site
UniProtKB:A0A8M2BIM5 InterPro	1034
UniProtKB:Q5ZEW1 InterPro	986
UniProtKB:A0A8M2BJ36 InterPro	1025
UniProtKB:A0A8M3AQD5 InterPro	940
UniProtKB:A0A8M2BIL7 InterPro	998
UniProtKB:A0A8M2BIL4 InterPro	989
UniProtKB:O13148 InterPro	292

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	epha4a-201 (1) Ensembl	Ensembl	4,795 nt	Select Tool ZFIN BLAST
mRNA	epha4a-202 (1) Ensembl	Ensembl	985 nt	Select Tool ZFIN BLAST
mRNA	epha4a-203 (1) Ensembl	Ensembl	3,387 nt	Select Tool ZFIN BLAST
mRNA	epha4a-205 (1) Ensembl	Ensembl	2,961 nt	Select Tool ZFIN BLAST
ncRNA	epha4a-003 (1) Ensembl	Ensembl	1,693 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations