Gene
jag2b
- ID
- ZDB-GENE-011128-3
- Name
- jagged canonical Notch ligand 2b
- Symbol
- jag2b Nomenclature History
- Previous Names
-
- jag2
- jagged2
- serB
- serrateB
- unp1068
- zgc:152855
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have Notch binding activity and calcium ion binding activity. Involved in animal organ development. Predicted to localize to plasma membrane and protein-containing complex. Is expressed in several structures, including anterior neural rod; digestive system; mesoderm; nervous system; and trunk. Orthologous to human JAG2 (jagged canonical Notch ligand 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 43 figures from 29 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1049 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Muscular dystrophy, limb-girdle, autosomal recessive 27 | 619566 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001007 | VWFC domain |
| Domain | IPR001774 | Delta/Serrate/lag-2 (DSL) protein |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR011651 | Notch ligand, N-terminal domain |
| Family | IPR026219 | Jagged/Serrate protein |
| Family | IPR050906 | Notch signaling pathway |
| Family | IPR051022 | Notch Signaling and Cell Fate Determination |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Jagged/Serrate protein | Notch ligand, N-terminal domain | Notch Signaling and Cell Fate Determination | Notch signaling pathway | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5TZK7
|
1216 | ||||||||||||
|
UniProtKB:Q90Y56
|
1254 |
Interactions and Pathways
Plasmids
No data available