Gene
fth1a
- ID
- ZDB-GENE-000831-2
- Name
- ferritin, heavy polypeptide 1a
- Symbol
- fth1a Nomenclature History
- Previous Names
-
- fth1 (1)
- fb06g09
- hm:zeh1145
- wu:fb06g09
- wu:fq18c10
- zeh1145
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to be involved in intracellular sequestering of iron ion. Predicted to act upstream of or within cellular iron ion homeostasis and iron ion transport. Predicted to be active in cytoplasm. Is expressed in blood; eye; liver; ovary; and testis. Human ortholog(s) of this gene implicated in hemochromatosis type 5. Orthologous to several human genes including FTH1 (ferritin heavy chain 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55220 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hemochromatosis type 5 | Alliance | ?Hemochromatosis, type 5 | 615517 |
| Neurodegeneration with brain iron accumulation 9 | 620669 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ferritin | Ferritin, conserved site | Ferritin/DPS protein domain | Ferritin-like | Ferritin-like diiron domain | Ferritin-like superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9DDT0
|
177 |
Interactions and Pathways
No data available
Plasmids
No data available