Gene

ngfb

ID

ZDB-GENE-000629-2

Name

nerve growth factor b (beta polypeptide)

Symbol

ngfb Nomenclature History

Previous Names

NGF
ngf
ngfb (1)
ns:zft386
xx:zft386
zgc:109730

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have growth factor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of neuron apoptotic process; and nervous system development. Predicted to localize to several cellular components, including axon; dendrite; and synaptic vesicle. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal failure; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Is expressed in several structures, including alar plate midbrain region; head mesenchyme; nervous system; periderm; and segmental plate. Orthologous to human NGF (nerve growth factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

25 figures from 10 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:109730 (16 images)
eu513 (20 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ngfb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary sensory and autonomic neuropathy type 5	Alliance	Neuropathy, hereditary sensory and autonomic, type V	608654

Associated With ngfb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019846	Nerve growth factor conserved site
Domain	IPR002072	Nerve growth factor-related
Family	IPR020408	Nerve growth factor-like
Homologous_superfamily	IPR029034	Cystine-knot cytokine

Domain Details Per Protein

Protein	Length	Cystine-knot cytokine	Nerve growth factor conserved site	Nerve growth factor-like	Nerve growth factor-related
UniProtKB:Q6YBR5 InterPro	194
UniProtKB:A0A8M1PAS0 InterPro	224
UniProtKB:B2GR51 InterPro	194

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ngfb-201 (1) Ensembl	Ensembl	1,301 nt	Select Tool
mRNA	ngfb-202 (1) Ensembl	Ensembl	1,187 nt	Select Tool
mRNA	ngfb-203 (1) Ensembl	Ensembl	1,057 nt	Select Tool
mRNA	ngfb-204 (1) Ensembl	Ensembl	1,039 nt	Select Tool
mRNA	ngfb-205 (1) Ensembl	Ensembl	773 nt	Select Tool
mRNA	ngfb-206 (1) Ensembl	Ensembl	1,291 nt	Select Tool
mRNA	ngfb-207 (1) Ensembl	Ensembl	588 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations