Gene

myf5

ID

ZDB-GENE-000616-6

Name

myogenic factor 5

Symbol

myf5 Nomenclature History

Previous Names

myf-5
cb641 (1)
zgc:110509

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in mesoderm development; muscle organ development; and neural crest cell development. Localizes to nucleolus and nucleoplasm. Is expressed in several structures, including mesoderm; musculature system; myoblast; pharyngeal arch; and post-vent region. Orthologous to human MYF5 (myogenic factor 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

99 figures from 62 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb641 (25 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myf5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Ophthalmoplegia, external, with rib and vertebral anomalies	618155

Associated With myf5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002546	Myogenic muscle-specific protein, N-terminal
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR022032	Myogenic determination factor 5
Family	IPR039704	Myogenic factor
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily