Gene
kat6b
- ID
- ZDB-GENE-000607-52
- Name
- K(lysine) acetyltransferase 6B
- Symbol
- kat6b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have histone acetyltransferase activity and histone binding activity. Predicted to be involved in histone H3 acetylation; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Predicted to localize to MOZ/MORF histone acetyltransferase complex and nuclear chromatin. Human ortholog(s) of this gene implicated in bipolar disorder; blepharophimosis-intellectual disability syndrome, SBBYS type; breast cancer; and leiomyoma. Is expressed in forebrain. Orthologous to human KAT6B (lysine acetyltransferase 6B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Kudoh et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ohdo syndrome, SBBYS variant | Alliance | SBBYSS syndrome | 603736 |
| Genitopatellar syndrome | 606170 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR002717 | Histone acetyltransferase domain, MYST-type |
| Domain | IPR005818 | Linker histone H1/H5, domain H15 |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR040706 | MYST, zinc finger domain |
| Domain | IPR048589 | SAM domain-containing protein 1-like, WH domain |
| Family | IPR050603 | MYST family histone acetyltransferases |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR016181 | Acyl-CoA N-acyltransferase |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Acyl-CoA N-acyltransferase | Histone acetyltransferase domain, MYST-type | Linker histone H1/H5, domain H15 | MYST family histone acetyltransferases | MYST, zinc finger domain | SAM domain-containing protein 1-like, WH domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B851
|
1856 | ||||||||||||
|
UniProtKB:A0A8M3BER5
|
2044 | ||||||||||||
|
UniProtKB:A0A8M3B5C9
|
1762 | ||||||||||||
|
UniProtKB:A0A8M3AZ79
|
2043 |
Interactions and Pathways
No data available
Plasmids
No data available