Gene
robo3
- ID
- ZDB-GENE-000209-4
- Name
- roundabout, axon guidance receptor, homolog 3 (Drosophila)
- Symbol
- robo3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have cell-cell adhesion mediator activity. Involved in axonogenesis and determination of ventral identity. Localizes to integral component of plasma membrane. Is expressed in several structures, including EVL; digestive system; fin; nervous system; and neural tube. Orthologous to human ROBO3 (roundabout guidance receptor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d102 (31 images)
- cb503 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Gaze palsy, familial horizontal, with progressive scoliosis, 1 | 607313 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR013106 | Immunoglobulin V-set domain |
| Domain | IPR032986 | Roundabout homologue 1, immunoglobulin-like domain 3 |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Roundabout homologue 1, immunoglobulin-like domain 3 |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A8DZ85
|
1389 | ||||||||||
|
UniProtKB:A0A8M2BJU1
|
1424 | ||||||||||
|
UniProtKB:A0A2R8QRK0
|
1420 | ||||||||||
|
UniProtKB:A0A8M6Z192
|
1393 | ||||||||||
|
UniProtKB:F1QFK4
|
1419 | ||||||||||
|
UniProtKB:A0A8M2BKE7
|
1423 |
Interactions and Pathways
No data available
Plasmids
No data available