Gene
igfbp2a
- ID
- ZDB-GENE-000125-12
- Name
- insulin-like growth factor binding protein 2a
- Symbol
- igfbp2a Nomenclature History
- Previous Names
-
- IGFBP-2
- igfbp2 (1)
- igfbp2b
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Exhibits insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including circulatory system development; negative regulation of growth; and regulation of insulin-like growth factor receptor signaling pathway. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in obesity. Is expressed in several structures, including brain; head; immature eye; testis; and yolk syncytial layer. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65741 (22 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017891 | Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site |
| Domain | IPR000716 | Thyroglobulin type-1 |
| Domain | IPR000867 | Insulin-like growth factor-binding protein, IGFBP |
| Family | IPR012210 | Insulin-like growth factor binding protein 2 |
| Family | IPR022321 | Insulin-like growth factor-binding protein family 1-6, chordata |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036857 | Thyroglobulin type-1 superfamily |
Domain Details Per Protein
| Protein | Length | Growth factor receptor cysteine-rich domain superfamily | Insulin-like growth factor binding protein 2 | Insulin-like growth factor-binding protein family 1-6, chordata | Insulin-like growth factor-binding protein, IGFBP | Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site | Thyroglobulin type-1 | Thyroglobulin type-1 superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9PTH3
|
276 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
igfbp2a-201
(1)
|
Ensembl | 1,748 nt |
Interactions and Pathways
No data available
Plasmids
No data available