RARE

ID

ZDB-EREGION-110816-18

Name

RARE

Symbol

RARE

Previous Names

• Retinoic acid response element

Location

Unmapped

Note

Retinoic Acid Response Elements (consensus RGKTCA, canonically G/AGGTCA), located in promoters or enhancers. RAR/RXR heterodimers bind to direct repeats of the RGKTCA motif (R = A/G, K = G/T) usually separated by 5 bases (Direct Repeat 5, DR5), but also to repeats of this motif with other spacing and orientations. The next most abundant motifs are also repetitions of the RGKTCA motif with different spacings (TR4 being a Direct Repeat separated by 1 and 2 bases : DR1/DR2) and orientations (Rxra being an Inverted Repeat with no base separation : IR0)