CRISPR

CRISPR2-scn1lab

ID

ZDB-CRISPR-200611-9

Name

CRISPR2-scn1lab

Previous Names

None

Target

scn1lab (1)

Sequence

5' - CTGCGCCTTCATGACGCTCAG - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
uio202	scn1lab

Expression

Gene expression in Wild Types + CRISPR2-scn1lab

No data available

Phenotype

Phenotype resulting from CRISPR2-scn1lab

No data available

Phenotype of all Fish created by or utilizing CRISPR2-scn1lab

Phenotype	Fish	Conditions	Figures
swim bladder inflation decreased occurrence, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. 1 from Tiraboschi et al., 2020
brain GABAergic neuron decreased amount, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. 3 from Tiraboschi et al., 2020
brain glutamatergic neuron decreased amount, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. 3 from Tiraboschi et al., 2020
optic tectum transmission of nerve impulse increased process quality, ameliorated	scn1lab^{uio202/uio202} (AB)	chemical treatment: diazepam	Fig. 1 from Tiraboschi et al., 2020
optic tectum transmission of nerve impulse increased process quality, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. 1 from Tiraboschi et al., 2020
brain astrocyte activation increased occurrence, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. 3 from Tiraboschi et al., 2020
optic tectum GABAergic neuron decreased branchiness, ameliorated	scn1lab^{uio202/uio202} (AB)	chemical treatment: fenfluramine	Fig. 4 from Tiraboschi et al., 2020
trunk bent, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. 1 from Tiraboschi et al., 2020
optic tectum transmission of nerve impulse increased process quality, ameliorated	scn1lab^{uio202/uio202} (AB)	chemical treatment: valproic acid	Fig. 1 from Tiraboschi et al., 2020
optic tectum mitotic S phase increased occurrence, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. 5 from Tiraboschi et al., 2020
brain slc17a7a expression increased amount, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. 3 from Tiraboschi et al., 2020
brain gad1b expression increased amount, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. 3 from Tiraboschi et al., 2020
pigmentation increased spatial extent of a process, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. 1 from Tiraboschi et al., 2020
swim bladder uninflated, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. 1 from Tiraboschi et al., 2020
optic tectum GABAergic neuron decreased branchiness, abnormal	scn1lab^{uio202/uio202} (AB)	chemical treatment: diazepam	Fig. 4 from Tiraboschi et al., 2020
optic tectum transmission of nerve impulse increased process quality, ameliorated	scn1lab^{uio202/uio202} (AB)	chemical treatment: fenfluramine	Fig. 1 from Tiraboschi et al., 2020
swimming increased occurrence, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. S2 from Tiraboschi et al., 2020
optic tectum mitotic S phase normal occurrence, ameliorated	scn1lab^{uio202/uio202} (AB)	chemical treatment: fenfluramine	Fig. 5 from Tiraboschi et al., 2020
radial glial cell brain increased amount, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. 2 from Tiraboschi et al., 2020
brain elavl3 expression increased amount, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. 3 from Tiraboschi et al., 2020
optic tectum GABAergic neuron decreased branchiness, abnormal	scn1lab^{uio202/uio202} (AB)	standard conditions	Fig. 4 from Tiraboschi et al., 2020

Citations