ZFIN Phenotype Statement: hematopoietic stem cell canonical Wnt signaling pathway increased occurrence, abnormal

Phenotype:	hematopoietic stem cell canonical Wnt signaling pathway increased occurrence, abnormal
Note:	This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name.

Name:	hematopoietic stem cell
Synonyms:	colony forming unit hematopoietic, hematopoietic progenitor cell, hemopoietic progenitor cell, hemopoietic stem cell, HSC
Definition:	A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.
Ontology:	Anatomy Ontology [ZFA:0009014]

Name:	canonical Wnt signaling pathway
Synonyms:	canonical Wnt receptor signaling pathway, canonical Wnt-activated signaling pathway, frizzled-1 receptor signaling pathway, Wnt receptor signaling pathway through beta-catenin, Wnt receptor signaling pathway via beta-catenin, Wnt receptor signalling pathway through beta-catenin
Definition:	A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Ontology:	GO: Biological Process [GO:0060070] QuickGO AmiGO

Name:	increased occurrence
Synonyms:	increased incidence
Definition:	An occurrence which is relatively high.
Ontology:	Phenotypic Quality Ontology [PATO:0002051]