Search Ontology:
GO: Biological Process

canonical Wnt signaling pathway

Term ID
GO:0060070
Synonyms
  • canonical Wnt receptor signaling pathway
  • canonical Wnt-activated signaling pathway
  • frizzled-1 receptor signaling pathway
  • Wnt receptor signaling pathway through beta-catenin
  • Wnt receptor signaling pathway via beta-catenin
  • Wnt receptor signalling pathway through beta-catenin
Definition
A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. (2)
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
has parts
is a type of
has subtype
negatively regulated by
positively regulated by
regulated by
Phenotype
Phenotype caused by Genes