ZFIN Image: Jamalpoor et al., 2021, D

Image

Figure Caption

D–J Toxicity profile of dimethyl α‐ketoglutarate (DMKG) and the drugs tested for the treatment of cystinosis

A

Cell viability curves of dimethyl α‐ketoglutarate (DMKG) in CTNS^WT and CTNS^−/− cells after 4 h of incubation in fed and starved condition (n = 3).

B, C

Cell viability curves of the increasing concentration of DMKG in control (CTNS^WT) and CRISPR‐generated cystinotic (CTNS^−/−) cells after 24 h of incubation in fed and starved condition, respectively (n = 3).

D–J

Cell viability test in CTNS^WT, CTNS^−/− cells treated with the increasing concentrations of cysteamine, bicalutamide, luteolin, genistein, 8‐bromo‐cAMP, disulfiram, and a combination of cysteamine and bicalutamide (100 and 35 µM, respectively), respectively (n = 3).

Data information: Data are expressed as mean ± SEM.

Acknowledgments

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