Gene

pcsk9

ID
ZDB-GENE-060927-1
Name
proprotein convertase subtilisin/kexin type 9
Symbol
pcsk9 Nomenclature History
Previous Names
  • NARC-1 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase activity. Involved in central nervous system development and neurogenesis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in hypobetalipoproteinemia. Is expressed in several structures, including eye; integument; liver; notochord; and pleuroperitoneal region. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pcsk9 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Hypercholesterolemia, familial, 3 603776
{Low density lipoprotein cholesterol level QTL 1} 603776
Associated With pcsk9 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR022398 Peptidase S8, subtilisin, His-active site
Domain IPR000209 Peptidase S8/S53 domain
Domain IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9
Domain IPR034193 Proteinase K-like catalytic domain
Domain IPR041051 Proprotein convertase subtilisin/kexin type 9, C-terminal domain 3
Domain IPR041254 Proprotein convertase subtilisin/kexin type 9, C-terminal domain 1
Family IPR015500 Peptidase S8, subtilisin-related
Family IPR050131 Subtilisin-like serine protease
Homologous_superfamily IPR036852 Peptidase S8/S53 domain superfamily
Homologous_superfamily IPR037045 Peptidase S8 propeptide/proteinase inhibitor I9 superfamily
Domain Details Per Protein
Protein Length Peptidase S8 propeptide/proteinase inhibitor I9 Peptidase S8 propeptide/proteinase inhibitor I9 superfamily Peptidase S8/S53 domain Peptidase S8/S53 domain superfamily Peptidase S8, subtilisin, His-active site Peptidase S8, subtilisin-related Proprotein convertase subtilisin/kexin type 9, C-terminal domain 1 Proprotein convertase subtilisin/kexin type 9, C-terminal domain 3 Proteinase K-like catalytic domain Subtilisin-like serine protease
UniProtKB:E7F2J6 667
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pcsk9 polyclonal Rabbit
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations