FIGURE

Figure 6

ID

ZDB-FIG-221211-161

Publication

Gao et al., 2022 - Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles

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Figure 6

Increasing cholesterol levels rescue hair cell defects and hearing in minar2 mutants.

(A) Quantification of D4H-mCherry in hair cells of wild type and minar2^fs139 zebrafish after efavirenz treatment. The lateral line L3 neuromast was imaged and quantified. n=40, 41, 42, and 41. F(3, 127.8)=7.557, p<0.001. (B) Quantification of AM1-43 labeling in wild type and mutant minar2^fs139 larvae after efavirenz treatment. n=31, 33, 33, and 30. F(3, 115.7)=46.65, p<0.0001. (C) Effects of efavirenz treatment on the appearance of abnormally enlarged vesicles in hair cells of wild type and mutant minar2^fs139 zebrafish. n=42, 38, 42, and 34. χ²=20.92, df = 3, p<0.001. (D) Effects of efavirenz treatment on C-start response rates for wild type and minar2^fs139 mutants (n=48 for all 4 groups. p<0.0001, Kruskal-Wallis test). DMSO: solvent control groups; Efa: efavirenz treatment groups. Multiple comparison significance values are indicated on the graph. Scale bars represent 10 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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