FIGURE

Fig. 4.

ID

ZDB-FIG-200509-27

Publication

de Oliveira et al., 2020 - DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of Fibrolamellar Carcinoma

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Fig. 4.

Overexpression ofzfDnaJa-Pkacainduces liver inflammation. (A) Representative MIPs of 7 dpf FLC larvae [Tg(fabp10a:dnajb1a-prkacaa)/Tg(fabp10a:egfp-l10a)/Tg(lyzc:bfp)/Tg(mpeg1:mCherry-caax)] and control siblings [Tg(fabp10a:egfp-l10a)/Tg(lyzc:bfp)/Tg(mpeg1:mCherry-caax)]. Dotted red lines indicate liver area. (B,C) Graphs showing macrophage (B) (control N=44, FLC N=50) and neutrophil (C) (control N=40, FLC N=48) density in the liver area. Scale bars: 40 μm. Data are from at least three independent experiments. Analysis performed in EMM in R. Dot plots show mean±s.e.m.; P-values are shown on graphs.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sh378Tg; uwm45Tg; uwm46Tg; zf2171Tg
Observed In:	liver liver macrophage liver neutrophil
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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