Term Name: | SeqA-DNA complex |
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Synonyms: | SeqA-dsDNA complex, SeqA-hemimethylated DNA complex, SeqA-hemimethylation dsDNA complex |
Definition: | A protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle. |
Ontology: | GO: Cellular Component [GO:1990097] QuickGO AmiGO |